Membranes organize proteins and other molecules enabling the cell to run much more efficiently than if everything were floating freely.
Mitochondrial membranes, for example, keep protein assembly lines together for efficient energy production. And the lysosome safely
holds enzymes that would destroy essential proteins if released into the cytoplasm. Membrane-enclosed vesicles form packages for cargo
so that they may quickly and efficiently reach their destinations. In this way, membranes divide the cell into specialized compartments,
each carrying out a specific function inside the cell.
Membranes Form Spontaneously
Phospholipids provide the framework for all membranes in the cell. Phospholipids are made up
of a phosphate head region and a lipid tail region. The two ends of a phospholipid have very
different chemical properties. The head end is attracted to water, while the tail end moves away
When phospholipids are placed into water, they organize themselves into a structure called a bilayer.
The water-fearing tail regions clump together on the inside of the bilayer, as far from water as
possible. The head regions move toward the outside of the bilayer where they contact the surrounding
The shape and chemical nature of phospholipids drives them to organize themselves one level
further. A flat phospholipid bilayer leaves the edges of the tails exposed to water. By forming
into a sphere, all of the tail regions are protected inside the bilayer as far from water as
possible. The result is a membrane-enclosed compartment.
Membrane Proteins Control Traffic
Phospholipid membranes form a barrier that most molecules cannot cross. But living things need
to be able to interact with the outside world. At the very least, waste must be able to go out
and raw materials need to come in. That's where membrane proteins come in. Membrane proteins that
contact the spaces on both sides of the membrane are the gate keepers of cellular compartments.
Each type of compartment has a specific population of membrane proteins that largely define its
function. On average, proteins make up about half the mass of membranes.
The nuclear pore complex (see scanning electron micrographs at right) is a unique protein
structure that controls traffic flow in and out of the nucleus. Each nuclear pore complex is
made up of hundreds of individual proteins.
Membranes Are Fluid
Phospholipids with their embedded proteins form a dynamic, fluid environment. Individual proteins and phospholipids
flow freely. Complexes of proteins and specific subtypes of phospholipids form "rafts" that move through the membrane.
Organelles stretch and bend and even flow through the cell. Fluid membranes allow cells to be dynamic and responsive
to their environment.
Genetic Science Learning Center. (2010, September 2) Membranes Organize Cellular Complexity.
Retrieved February 24, 2017, from http://learn.genetics.utah.edu/content/cells/membranes/
Membranes Organize Cellular Complexity [Internet]. Salt Lake City (UT): Genetic Science Learning Center; 2010
[cited 2017 Feb 24] Available from http://learn.genetics.utah.edu/content/cells/membranes/
Genetic Science Learning Center. "Membranes Organize Cellular Complexity." Learn.Genetics.September 2, 2010. Accessed February 24, 2017. http://learn.genetics.utah.edu/content/cells/membranes/.