Nutrient |
Food Origin |
Epigenetic Role |
Methionine |
Sesame seeds, brazil nuts, fish, peppers, spinach |
SAM synthesis |
Folic Acid |
Leafy vegetables, sunflower seeds, baker's yeast, liver |
Methionine synthesis |
Vitamin B12 |
Meat, liver, shellfish, milk |
Methionine synthesis |
Vitamin B6 |
Meats, whole grain products, vegetables, nuts |
Methionine synthesis |
SAM-e (SAM) |
Popular dietary supplement pill; unstable in food |
Enzymes transfer methyl groups from SAM directly to the DNA |
Choline |
Egg yolks, liver, soy, cooked beef, chicken, veal and turkey |
Methyl donor to SAM |
Betaine |
Wheat, spinach, shellfish, and sugar beets |
Break down the toxic byproducts of SAM synthesis |
Resveratrol |
Red wine |
Removes acetyl groups from histones, improving health (shown in lab mice) |
Genistein |
Soy, soy products |
Increased methylation, cancer prevention, unknown mechanism |
Sulforaphane |
Broccoli |
Increased histone acetylation turning on anti-cancer genes |
Butyrate |
A compound produced in the intestine when dietary fiber is fermented |
Increased histone acetylation turning on 'protective' genes, increased lifespan (shown in the lab in flies) |
Diallyl sulphide (DADS) |
Garlic |
Increased histone acetylation turning on anti-cancer genes |