How can we improve the effectiveness and safety of medications?
In Making SNPs Make Sense you learned that scientists can determine individual SNP profiles to identify differences in our DNA. In the coming years we can expect research in pharmacogenetics, using SNP profiles and other types of DNA analysis, to provide safer and more effective drug therapies for everyone.
Here is the problem: Four young amphibians have found that their normally sleek and slippery green skin is now covered in warty eruptions, yuk! These frustrated frogs are willing to try anything to get rid of their warts, so they've volunteered to be test subjects for some new medications.
Finding a solution: Gribbenhopp Pharmaceutical Company has developed three new wart medications and they would like you to test them out on these four warty and willing volunteers.
Gribbenhopp cannot afford to market all three drugs, so they have asked you to identify the one "wart remedy" that will cure the most frogs with the least side effects. Determine each frog's SNP profile, test the drugs and make predictions based on your results. Then take your study data back to the pharmaceutical company to help them decide which drug would be best to develop and market.
Are you ready?
Click on a file below to download and play Pus-Poppin' Frogs!
Supported by a Science Education Partnership Award (SEPA) [No. 1 R25 RR16291-01] from the National Center for Research Resources, a component of the National Institutes of Health, Department of Health and Human Services. The contents provided here are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.