Plexiform neurofibromas

Plexiform (PLECKS-i-form) neurofibromas are tumors that spread out, either just under the skin or deeper in the body. The word "plexus" refers to a combination of interlaced parts, or a network. Plexiform neurofibromas can grow in many places, such as on the face, down the leg or on the spinal column, and they can be disfiguring.

Do plexiform neurofibromas ever become cancerous? They can become cancerous, but this is rare. Do they cause other problems? Yes, they can cause a range of problems from minor discomfort to extreme pain. If they grow on the spinal column, they can cause paralysis. When do they show up? Plexiform neurofibromas can appear at any age, but they usually begin to show up in late childhood or early adolescence. Can they be removed? Because they grow around nerves and spread out, plexiform neurofibromas are difficult to remove. When removed, they tend to regrow. In cases where the neurofibroma might cause paralysis or other life-threatening problems, a surgeon may try to remove part or all of it. How common are they? Plexiform neurofibromas occur in about 15 percent of people with NF1.